Cardiac arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF) are a leading cause of sudden cardiac death in industrialized countries. Despite decades of research the underlying mechanism of cardiac arrhythmias such as VF is still not clearly understood. Experimental studies suggest that spiral or scroll waves of electrical activation in cardiac tissue are associated with VT, whereas, when these waves break to yield spiral- or scroll-wave turbulence, VT develops into life-threatening VF. Thus, studies of spiral- and scroll-wave dynamics in cardiac tissue pose important challenges for in vivo and in vitro experimental studies and for in silico numerical studies of mathematical models for cardiac tissue.
We are studying following mathematical models for ventricular tissue:
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1. Luo-Rudy I model (LRI) (1991)
A model of the ventricular cardiac action potential, depolarization, repolarization and their interaction.
2. Bernus-Wilders-Zemlin-Verschelde-Panfilov model (RPB) (2002)
A computationally efficient electrophysiological model of human ventricular cells.
3. ten Tusscher-Noble-Noble-Panfilov model (TNNP) (2004)
A model for human ventricular tissue.
4. ten Tusscher-Panfilov model (TP06) (2006)
Alternans and spiral breakup in a human ventricular tissue model.
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